Selank

CLASSIFICATION Anxiolytic Peptide
ACNE No
WATER RETENTION No
HBR No
HEPATOTOXICITY No
AROMATIZATION No
MANUFACTURER Deus Medical
LAB TEST See Document
WAREHOUSE EU Warehouse 2
SUBSTANCE Selank Anxiolytic Peptide ,

In the ever-evolving field of biotechnology, innovative biologically active substances, including "cognitive enhancers" or "nootropics," have garnered significant attention. One such standout is Selank, previously known as ?TP-7.? This synthetic peptide is a carefully crafted small protein recognized for its potential in anxiety relief and cognitive enhancement.

Marketed as an effective "anti-anxiety" agent, Selank claims to support learning and increase energy levels without the risk of side effects or addiction. Developed through a collaboration between the Institute of Molecular Genetics (Russian Academy of Sciences) and the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), Selank is closely related to another peptide called Semax.

Selank?s formulation combines the sequence of a naturally occurring peptide, tuftsin, which is part of the antibody IgG, with a stabilizing sequence to enhance its efficacy. Research suggests that both tuftsin and Selank can alleviate anxiety and elevate serotonin levels in animal models, with Selank demonstrating slightly superior results.

Although Selank has been authorized for treating generalized anxiety disorder (GAD) in Russia and is utilized as a nootropic, it remains unapproved by the FDA for any medical conditions in the U.S. Nevertheless, Selank is accessible in various countries, often as a "nutritional supplement."

While the exact mechanisms of Selank are not fully understood, it is thought to stabilize enkephalins in the bloodstream, which may help modulate the body's stress response. However, one study on mice did not confirm enkephalin stabilization after Selank administration, nor did it show significant anti-anxiety effects.

Some cellular studies suggest that Selank may interact with GABA receptors, which are known for their sedative properties. One mouse study indicated that Selank treatment was associated with heightened activity in GABAergic inhibitory neurons, leading to decreased overall brain activity similar to sedation.

Moreover, researchers have observed an increase in BDNF (brain-derived neurotrophic factor), crucial for learning and memory, which may account for some of Selank's cognitive benefits. Additionally, it appears to influence neurotransmitter levels?norepinephrine, dopamine, and serotonin?vital for motivation, focus, and pleasure.

However, one animal study indicated that while Selank elevated norepinephrine levels, it lowered dopamine and serotonin, while another study reported increases in norepinephrine and dopamine without affecting serotonin. Thus, Selank's precise effects and mechanisms warrant further exploration.

A preliminary clinical trial with 62 participants suggested that Selank could effectively reduce anxiety symptoms, especially in those with anxiety disorders. Similarly, another study involving 60 participants reported lasting benefits for up to a week after the last dose. In a separate study with 70 anxiety patients, Selank was found to enhance the effects of phenazepam (an anti-anxiety medication banned in some U.S. states due to misuse) while minimizing side effects such as drowsiness and memory loss. Animal studies also support Selank's efficacy in reducing anxiety in mice, particularly those with higher baseline anxiety levels.

While evidence is limited, these findings suggest Selank may offer anxiety relief, although further research is essential to confirm its safety and efficacy in humans. If you experience anxiety, consult your healthcare provider to discuss whether Selank could be a suitable option, while always following their guidance over supplements.

Selank has shown promise in stabilizing memory traces in rats, potentially enhancing memory retention during a 30-day trial, although the methods for measuring memory remain ambiguous. Additionally, one study indicated that Selank may help preserve memory in monkeys, yet human research is necessary to determine its effects on healthy individuals and establish safety protocols.

In one study, rats with toxin-induced brain damage treated with Selank exhibited restored brain activity to normal levels.

Selank has also been shown to alleviate depressive symptoms in mice, with lower doses proving more effective than higher doses.

Preliminary animal research indicates Selank injections increased antioxidant levels in the livers of stressed mice.

In sedated cats, Selank was reported to reduce blood pressure by about 30% for up to three minutes and enhance brain blood flow by around 24% for up to ten minutes. While these findings are intriguing, their short duration complicates potential clinical significance and raises questions about their applicability to healthy humans.

Selank may also help mitigate anxiety associated with alcohol withdrawal. In a study simulating high alcohol intake, rats treated with Selank after 48 hours of withdrawal exhibited reduced anxiety levels.

In a study, rats on a high-fat diet showed 35% less weight gain with Selank treatment, alongside significant reductions in total cholesterol (over 58%) and blood glucose levels (23.5%).

In another study, mice with breast cancer treated with Selank showed slower tumor growth and prolonged survival compared to untreated mice. However, these early findings do not imply that Selank is an effective cancer treatment, and any conventional cancer therapies should not be replaced with Selank or other supplements.

Post-treatment, the spleens of mice exhibited elevated levels of several inflammatory response genes, suggesting potential protective effects against inflammation.

Selank has also been observed to reduce stomach ulcer size in animal models, possibly due to increased lymph flow to the stomach, which is crucial for immune function. Nonetheless, substantial human research is needed to validate these effects and their mechanisms.

Furthermore, Selank was reported to elevate IL-6 levels in blood cells from depressed patients, with IL-6 being an inflammatory protein involved in infection defense. One cell-based study suggested Selank might stimulate interferon release, molecules that combat viral infections, although an animal study did not support any antiviral benefits from Selank treatment.