Duphaston

CLASSIFICATION
Progesterone Agonist
DOSAGE
10-30 mg/day
ACNE
No
WATER RETENTION
No
HBR
Perhaps
HEPATOTOXICITY
Yes
AROMATIZATION
No
MANUFACTURER
Abbott
WAREHOUSE
International Warehouse 2
SUBSTANCE
Dydrogesterone

Duphaston is a highly effective medication featuring dydrogesterone as its active ingredient, classified as a progesterone agonist (a vital female sex hormone). It plays a key role in reducing the risk of endometrial hyperplasia.

This medication is typically prescribed for various conditions, including:

• Irregular menstrual cycles
• Dysmenorrhea (painful periods)
• Endometriosis
• Infertility

When combined with estrogen, Duphaston can also effectively treat secondary amenorrhea (absence of menstrual periods for six months or more) and manage heavy or irregular bleeding.

Duphaston is contraindicated in certain situations, including:

• Individuals with allergies to dydrogesterone or similar medications. If you experience symptoms like skin rash, itching, redness, swelling, or difficulty breathing, seek medical assistance immediately.
• Those with deep vein thrombosis (blood vessel blockage).
• Patients with cancers dependent on progesterone or estrogen.
• Individuals experiencing unexplained bleeding.
• Patients with liver dysfunction; this medication may impact liver health, so contact your healthcare provider if you notice symptoms like right upper abdominal pain, loss of appetite, dark urine, or jaundice (yellowing of skin and eyes).
• People with depression.
• Patients with porphyria.

While using Duphaston, regular breast self-exams are recommended due to an increased breast cancer risk when combined with estrogen.

Duphaston should only be used during pregnancy if specifically prescribed by a healthcare professional. It can pass into breast milk, so breastfeeding is not advised while taking Duphaston.

Your doctor will determine the exact dosage for you; self-medication is not advised. Take the tablet whole with a glass of water?do not crush or chew.

Be cautious when using Duphaston with the following medications:

• Antiepileptic drugs, including carbamazepine, phenytoin, and phenobarbital, as they may decrease Duphaston levels and effectiveness.
• HIV medications such as ritonavir, indinavir, and saquinavir.
• Herbal products like St. John's wort, sage, and ginkgo biloba, which can also reduce Duphaston efficacy.

Always inform your doctor about all medications and herbal supplements you are taking.

Duphaston may cause side effects, including:

• Nausea
• Vomiting
• Headache
• Dizziness
• Weight gain
• Breast swelling
• Anemia
• Depression
• Fatigue
• Liver damage (loss of appetite, right upper abdominal pain, jaundice)
• Allergic reactions, among others.

If you experience any side effects, please notify your doctor promptly.