ACTIVE HALF-LIFE
4-5 hours
CLASSIFICATION
SNRIs & PDE5 Inhibitor
DOSAGE
Men: 130 mg/day
ACNE
No
WATER RETENTION
No
HBR
Possible
HEPATOTOXICITY
No
AROMATIZATION
No
MANUFACTURER
Sunrise Remedies
WAREHOUSE
International Warehouse 1
SUBSTANCE
Duloxetine, Sildenafil
Introducing Malegra DXT by Sunrise Remedies?a powerful formulation that combines the benefits of Sildenafil and Duloxetine, designed specifically to enhance your sexual experience. Sildenafil effectively addresses erectile dysfunction, while Duloxetine helps manage premature ejaculation, ensuring a more satisfying intimate encounter. Although typically available by prescription, Malegra DXT can be conveniently purchased online. However, due to potential interactions with other medications, consulting a healthcare professional prior to use is essential. This product is offered exclusively in oral capsule form.
How It Works:During sexual excitement, nitric oxide is released from the corpus cavernosum, a crucial element for achieving and maintaining an erection. This process stimulates guanylate cyclase, resulting in elevated levels of cGMP (cyclic guanosine monophosphate). Increased cGMP promotes relaxation of the smooth muscle in the corpus cavernosum, allowing for enhanced blood flow to the penis. Sildenafil amplifies the effects of nitric oxide by inhibiting PDE5 (Phosphodiesterase type 5), the enzyme responsible for breaking down cGMP. It's important to note that Sildenafil requires sexual stimulation to be effective, activating only when arousal triggers nitric oxide release. Administered orally, Sildenafil is rapidly absorbed?usually within one hour?via hepatic metabolism involving cytochrome P450 3A4, leading to the production of an active metabolite.
Duloxetine, a thiophene derivative, acts as a selective serotonin reuptake inhibitor, reducing anxiety during sexual activities. This mechanism helps to prolong intercourse by slowing down sensation in the glans penis, effectively preventing premature ejaculation.
Dosage:Malegra DXT serves as a dual-action solution for sexual dysfunction, containing 100 mg of Sildenafil and 30 mg of Duloxetine. Sildenafil is absorbed quickly, generally within 30 minutes, promoting increased blood flow that allows for an erection within one hour, lasting up to 4-5 hours. Meanwhile, Duloxetine targets the nervous system to alleviate anxiety during intimate moments, further assisting in the prevention of premature ejaculation.
Available in two dosages?75 mg and 130 mg?physicians often recommend the 130 mg option for optimal effectiveness. It's advised to take one tablet one hour before sexual activity, and users should avoid exceeding one dose per day.
Side Effects:Malegra DXT is typically well-tolerated and safe for most users. While side effects are rare, they may occur due to the dilation of blood vessels and could include nausea, insomnia, flushing, muscle pain, dyspepsia, dizziness, vomiting, loose stools, epistaxis, and erythema.
Drug Interactions:Malegra DXT can lower blood pressure when combined with alpha blockers. Additionally, interactions with erythromycin or cimetidine may extend the duration of an erection.

